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Mannheim, Germany: The oral administration of 800 mg of synthetic CBD significantly reduces subjects’ cravings for alcohol, according to placebo-controlled clinical data published in the journal Nature: Molecular Psychiatry.
German researchers assessed the use of CBD versus placebo in 28 subjects who consumed alcohol daily.
“Individuals receiving CBD … reported significantly lower alcohol cravings,” investigators wrote. “No adverse events or serious adverse events were reported by the participants of the study during the test session.”
The study’s authors concluded: “The current RCT [randomized clinical trial] provides evidence for the significant effects of CBD on neurobiological disease mechanisms and symptoms in AUD. … In summary, the observed potential of CBD to reduce cue-induced … alcohol craving, together with its good safety profile, supports the potential of CBD to treat individuals with AUD [alcohol use disorder]. New pharmacological treatment options that target central neurobiological disease mechanisms and core symptoms of AUD, such as craving, could complement existing treatment options and reduce relapse risk and the enormous disease burden inflicted by AUD.”
A 2021 observational study determined that the consumption of CBD-dominant cannabis is associated with reductions in subjects’ alcohol intake. The authors of the study reported that participants who ingested CBD-dominant cannabis during the trial period “drank fewer drinks per drinking day, had fewer alcohol use days, and fewer alcohol and cannabis co-use days” compared with those who did not.
Separate studies have also suggested that CBD dosing can reduce cravings for tobacco, methamphetamine, and heroin, among other substances.
Full text of the study, “Cannabidiol administration reduces alcohol cravings and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: The double-blind randomized controlled ICONIC trial,” appears in Nature: Molecular Psychiatry.
“}]] Clinical trial assessed the use of CBD versus placebo Read More
