[#item_full_content] Conventional approaches for determining limits of detection (LOD), such as signal-to-noise ratios and repeated measurement methods designed for single-signal detection, can result in unrealistic LOD values because they often fail to account for multi-signal identification and the disproportionate generation of analyte and noise signals in mass spectrometry techniques such as selected ion monitoring (SIM) and multiple reaction monitoring (MRM). This article proposes a practical alternative compared to standard approaches. 
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